CARDIUM Therapeutics: Resources
Articles | Clinical Studies | Websites | Annual Reports & Brochures
ARTICLES: Tissue Repair
Mulder, G, Tallis A, Marshall T, Mozingo, D, Phillips, L, Pierce, G, Chandler L, Sosnowski B. Treatment of Nonhealing Diabetic Foot Ulcers with a Platelet-Derived Growth Factor Gene-Activated Matrix (GAM501): Results of a Phase 1/2 trial. Wound Repair and Regeneration. 17(6): 772-779 (2009).
Chang PC, Seol YJ, Cirelli JA, Pellegrini G, Jin Q, Franco LM, Goldstein SA, Chandler LA, Sosnowski B, Giannobile WV. PDGF-B gene therapy accelerates bone engineering and oral implant osseointegration. Gene Therapy (10 September 2009) doi:10.1038/gt.2009.117
Chang PC, Cirelli JA, Jin Q, Seol YJ, Sugai JV, D'Silva NJ, Danciu TE, Chandler LA, Sosnowski BA, Giannobile WV. Adenovirus Encoding Human Platelet-Derived Growth Factor-B Delivered to Alveolar Bone Defects Exhibits Safety and Biodistribution Profiles Favorable for Clinical Use. Hum Gene Ther. 20:486-496 (2009).
Schreiber RE, Blease K, Ambrosio A, Amburn E, Sosnowski B, Sampath TK. Bone induction by AdBMP-2/collagen implants. J Bone Joint Surg Am. 87(5):1059-68 (2005).
Gu DL, Nguyen T, Phillips L., Chandler LA, Sosnowski B. Matrix-immobilized growth factor gene therapy enhances tissue repair. Wounds 16(1): 34-41 (2004).
Gu DL, Nguyen T, Gonzalez AM, Printz MA, Pierce GF, Sosnowski BA, Phillips ML, Chandler LA. Adenovirus encoding human platelet-derived growth factor-B delivered in collagen exhibits safety, biodistribution, and immunogenicity profiles favorable for clinical use. Mol Ther. 9(5):699-711 (2004).
Doukas J, Chandler LA, Gonzalez AM, Gu D, Hoganson DK, Ma C, Nguyen T, Printz MA, Nesbit M, Herlyn M, Crombleholme TM, Aukerman SL, Sosnowski BA, Pierce GF. Matrix immobilization enhances the tissue repair activity of growth factor gene therapy vectors. Hum Gene Ther. 12(7):783-98 (2001).
Chandler LA, Gu DL, Ma C, Gonzalez AM, Doukas J, Nguyen T, Pierce GF, Phillips ML. Matrix-enabled gene transfer for cutaneous wound repair. Wound Repair Regen. 8(6):473-9 (2000).
ARTICLES: Heart Disease and GENE Therapy
In Heart Disease, the Focus Shifts to Women, New York Times, April 18, 2006.
WISE study of women and heart disease yields important findings on frequently undiagnosed coronary syndrome, National Institutes of Health report, January 31, 2006 (http://www.nhlbi.nih.gov/new/press/06-01-31.htm).
Meier et al, Circ. 2007; 116:975-983 - This long-term study published in the American Heart Association’s Journal, Circulation, evaluated coronary collateral blood flow in 845 patients with coronary artery disease during a 10-year follow-up period and demonstrated that long-term cardiac mortality was reduced by 75% in patients with a highly developed collateral vessel blood supply (p=0.0395).
Advanced Gene Therapy Products. Compiled by Cardium Therapeutics, March 2010.
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CLINICAL STUDIES |
AGENT – “Angiogenic Gene Therapy (AGENT) trial in patients with stable angina pectoris ”, Grines et al. (2002) Circulation 105(11):1291-1297.
AGENT-2 – “A randomized, double-blind, placebo-controlled trial of Ad5FGF-4 gene therapy and its effect on myocardial perfusion in patients with stable angina”, Grines et al. (2003) Journal of the American College of Cardiology 42(8):1339-1347.
AGENT Clinical Trials Review – “The AGENT clinical trials programme”, Grines (2004) European Heart Journal Supplement 6(Suppl E):E18-E23.
AGENT-3 and AGENT-4 – “Effects of Ad5FGF-4 in patients with angina: an analysis of pooled data from the AGENT-3 and AGENT-4 trials”, Henry et al. (2007) Journal of the American College of Cardiology 50(11):1038-1046.
(For reprints please contact Cardium)
WEBSITES
American Diabetes Association, www.diabetes.org
American Heart Association, www.americanheart.org
The American Society of Gene Therapy (ASGT), www.asgt.org
Go
Red for Women, www.goredforwomen.org
National Women's Health Resource Center, www.Healthywomen.org
National Coalition of Women with Heart Disease, www.womenheart.org
National Heart, Lung and Blood Institute, www.nhlbi.nih.gov
World Health Organization, www.who.int/cardiovascular_diseases/en/