Tissue Engineering Technology: Excellagen
Excellagen
Excellagen™ is a new, highly-refined formulated fibrillar bovine Type I collagen-based topical gel (2.6% collagen concentration) designed to support a favorable wound healing environment which has received FDA 510(k) clearance for the management of diabetic ulcers, partial and full thickness wounds, pressure ulcers, chronic vascular ulcers, tunneled/undermined wounds, surgical wounds (donor sites/grafts, post-Moh's surgery, post-laser surgery, podiatric, wound dehiscence), trauma wounds (abrasions, lacerations, second-degree burns, skin tears) and draining wounds.
Electron Microscope Image
of Fibrillar Collagen
Excellagen is manufactured to strict quality and safety standards using a specialized process designed to generate full-length, native, fibrillar collagen.
Excellagen is designed for use by health care professionals in a clinical setting and its directions for use indicate application immediately following surgical debridement and in the presence of a small influx of blood. Studies have shown that collagen can activate the release of PDGF (and potentially other important growth factors) from platelets.
Excellagen is formulated in a specialized, physiologic buffer that ensures retention of its key structural and functional properties and allows for easy application to wounds of a variety of shapes and sizes. Excellagen requires storage at standard refrigeration temperature (2-8°C) and is supplied in the form of a kit consisting of four sterile single-use 1.0 cc syringes, each containing 0.5 cc of Excellagen gel, and four sterile flexible applicators. Excellagen is biocompatible so there is no need for daily dressing changes or to remove Excellagen between weekly clinic visits.
Formulated collagen gel accelerates healing rate immediately after application in patients with diabetic neuropathic foot ulcers.
The Excellagen product platform also provides the opportunity to develop and introduce additional new product opportunities by incorporating other agents into the Excellagen formulation, such as antimicrobials, DNA and/or other biologics, that would be designed to address particular wound healing and other tissue repair applications.
A recent publication from a Phase 2b clinical study in diabetic neuropathic ulcers reported that application of 2.6% formulated fibrillar collagen resulted in a statistically significant 173% relative improvement in the acceleration of healing (reduction in wound radius) during the first week following a one-time application compared to patients receiving standard of care therapy.1
For more information about Excellagen, visit www.excellagen.com.
1 Blume, P., Driver, V. R., Tallis, A. J., Kirsner, R. S., Kroeker, R., Payne, W. G., Wali, S., Marston, W., Dove, C., Engler, R. L., Chandler, L. A. and Sosnowski, B. K. (2011), Formulated collagen gel accelerates healing rate immediately after application in patients with diabetic neuropathic foot ulcers. Wound Repair and Regeneration, 19: 302–308. doi: 10.1111/j.1524-475X.2011.00669.